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Human CellExp™ RAGE / AGER, Fc Tag, Human Recombinant

Mediates interactions of advanced glycosylation end products (AGE)
Catalog #: P1231

In stock

SKU-Size Size Price Qty
P1231-10 10 μg
$110.00
P1231-50 50 μg
$305.00

Product Details

Alternate Name AGER, RAGE
Gene Symbol AGER
Gene ID 177
Accession # Q15109
Source HEK 293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH 7.5. Normally trehalose is added as protectant before lyophilization.
Molecular Weight 60.8 kDa
Purity by SDS-PAGE > 60%
Endotoxin Level < 1.0 EU per/μg
Biological Activity Immobilized Human RAGE, Fc Tag (Cat. No. AGR-H5253) at 20 μg/mL (100 μL/well) can bind Human HMGB1, His Tag (Cat. No. HM1-H5220) with a linear range of 0.313-5 μg/mL
Reconstitution Instructions Reconstitute in sterile deionized water to the desired protein concentration.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Advanced glycosylation end product-specific receptor (AGER) is also known as RAGE, and is a single-pass type I membrane protein which contains two Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. AGER is highly expressed in endothelial cells. AGER mediates interactions of advanced glycosylation end products (AGE), and also accumulates in vascular tissue in aging and at an accelerated rate in diabetes, as well as acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGER / RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes.


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