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Human CellExp™ Properdin, Human Recombinant

A positive regulator of the alternate pathway of complement
Catalog #: P1470
SKU-Size Size Price Qty
P1470-10 10 µg
$105.00
P1470-50 50 µg
$395.00
More Sizes Get Quote

Product Details

Alternate Name Properdin, Complement factor P, CFP, PFC
Gene Symbol CFP
Gene ID 5199
Accession # P27918
Source HEK 293 cells
Appearance Lyophilized powder
Physical Form Description Lyophilized
Molecular Weight This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 50.7 kDa. The protein migrates as 55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity by SDS-PAGE >90%
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Reconstitution Instructions Reconstitute in sterile deionized water to the desired protein concentration.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Properdin is also known as Complement factor P, CFP, PFC, a positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes. Properdin is produced by many different leukocyte subsets and circulates as cyclic oligomers of monomeric subunits. Properdin on platelet/granulocyte aggregates(PGA) formation are tightly regulated by Factor H, properdin enhances PGA formation via increased production of C5a, and that inhibition of properdin function has therapeutic potential to limit thromboinflammation in diseases characterized by increased PGA formation.


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