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Human CellExp™ Progranulin (untagged), Mouse Recombinant

Regulator of cell growth, wound healing, and tumorigenesis
Catalog #: 4733
SKU-Size Size Price Qty
4733-10 10 μg
$240.00
4733-50 50 μg
$810.00
More Sizes Get Quote

Product Details

Alternate Name Proepithelin, PEPI, PC Cell-derived Growth Factor.
Gene Symbol GRN
Gene ID 10090
Accession # P28798
Source HEK 293 cells
Appearance Lyophilized protein
Physical Form Description Lyophilized from 0.2 μm-filtered solution in PBS, pH 7.2.
Molecular Weight ~65.0 kDa
Purity by SDS-PAGE ≥95%
Endotoxin Level <0.1 EU/µg purified protein
Reconstitution Instructions Reconstitute in distilled water
Amino Acid Sequence Signal peptide and mouse progranulin (aa 1-589) is untagged. Reflects the native sequence with no additional amino acids.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Progranulin (PGRN), also called proepithelin and PC cell-derived growth factor, is a single precursor protein of granulins which are a family of secreted, glycosylated peptides. It is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of fronto-temporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer‘s Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.


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