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Human CellExp™ Progranulin, Mouse Recombinant

Regulator of cell growth, wound healing, and tumorigenesis
Catalog #: 4734
SKU-Size Size Price Qty
4734-10 10 μg
$220.00
4734-50 50 μg
$765.00
More Sizes Get Quote

Product Details

Alternate Name Proepithelin; PEPI; PC Cell-derived Growth Factor
Gene Symbol GRN
Gene ID 10090
Accession # P28798
Source HEK 293 cells
Appearance Liquid
Physical Form Description 0.2 μm-filtered solution in PBS
Molecular Weight ~70.0 kDa
Purity by SDS-PAGE ≥95%
Endotoxin Level <0.1 EU/μg purified protein
Amino Acid Sequence Signal peptide and mouse Progranulin (aa 1-589) fused at the C-terminus to a FLAG®-tag.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Progranulin (PGRN), also called proepithelin and PC cell-derived growth factor, is a singleprecursor protein of granulins which are a family of secreted, glycosylated peptides. It is awidely expressed pluripotent growth factor which plays a role in processes such asdevelopment, wound repair and inflammation by activating signaling cascades that control cellcycle progression and cell motility. Its function in the central nervous system is of interest, asmutations in the PGRN gene were found in cases of fronto-temporal degeneration (FTLD). Inaddition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD,other types of Alzheimer‘s Disease (AD) and potentially for MCI (Mild Cognitive Impairment).Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeuticagainst inflammatory disease like arthritis. Mouse Recombinant Progranulin fused to FLAG®at C-terminus produced in HEK is a single, glycosylated, polypeptide chain purified bystandard chromatographic techniques, containing 589 amino acids and having a molecularmass of ~70.0 kDa.


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