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Human CellExp™ OX40 Ligand / TNFSF4, Mouse Recombinant

A costimulatory molecule implicated in long-term T-cell immunity, also cts as a receptor for human herpesvirus 6B/HHV-6B
Catalog #: P1232

In stock

$175.00

Product Details

Cat # +Size P1232-10
Size 10 μg
Alternate Name OX40L, TNFSF4, CD252, Glycoprotein Gp34, TXGP1
Gene Symbol Tnfsf4
Gene ID 22164
Accession # P43488
Source HEK 293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Generally Mannitol or Trehalose is added as a protectant before lyophilization.
Molecular Weight 18.3 kDa
Purity by SDS-PAGE > 90%
Endotoxin Level < 1.0 EU per/μg
Biological Activity Immobilized Mouse OX40, Fc Tag at 5 μg/mL (100 μL/well) can bind Mouse OX40 Ligand, His Tag with a linear range of 0.5-16 ng/mL
Reconstitution Instructions Reconstitute in sterile deionized water to the desired protein concentration.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported.


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