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Human CellExp™ Noggin, Human Recombinant

An inhibitor of TGF-β signal transduction
Catalog #: 6474
SKU-Size Size Price Qty
6474-10 10 µg
$230.00
6474-50 50 µg
$940.00
More Sizes Get Quote

Product Details

Alternate Name SYM1, SYNS1, NOG.
Gene Symbol NOG
Gene ID 9241
Accession # Q13253
Source Human 293 cell expressed
Appearance Lyophilized
Physical Form Description Lyophilized in PBS.
Molecular Weight 65 kDa, homodimer, glycosylated
Purity by SDS-PAGE > 95%
Endotoxin Level < 1.0 EU per 1 μg of protein
Biological Activity ED₅₀ is typically 20 to 100 ng/mL. The specific activity was determined by the dose-dependent inhibition of rhBMP4 induced alkaline phosphate production by ATDC5 cells.
Reconstitution Instructions Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis.


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