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Product Details
| Alternate Name | SYM1, SYNS1, NOG. |
|---|---|
| Gene Symbol | NOG |
| Gene ID | 9241 |
| Accession # | Q13253 |
| Source | Human 293 cell expressed |
| Appearance | Lyophilized |
| Physical Form Description | Lyophilized in PBS. |
| Molecular Weight | 65 kDa, homodimer, glycosylated |
| Purity by SDS-PAGE | > 95% |
| Endotoxin Level | < 1.0 EU per 1 μg of protein |
| Biological Activity | ED₅₀ is typically 20 to 100 ng/mL. The specific activity was determined by the dose-dependent inhibition of rhBMP4 induced alkaline phosphate production by ATDC5 cells. |
| Reconstitution Instructions | Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not to be used in humans |
Details
Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis.
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