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Human CellExp™ Nectin-2 / CD112, Human Recombinant

Modulator of T-cell signaling.
Catalog #: P1371

In stock

SKU-Size Size Price Qty
P1371-10 10 µg
$95.00
P1371-50 50 µg
$345.00
More Sizes Get Quote

Product Details

Alternate Name CD112, Nectin-2, PVRL2
Gene Symbol NECTIN2
Gene ID 5819
Accession # Q92692
Source HEK 293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered solution in PBS, pH5.0. Normally trehalose is added as protectant before lyophilization.
Molecular Weight 37.4 kDa
Purity by SDS-PAGE ≥95%
Endotoxin Level < 1.0 EU per 1 μg of protein
Biological Activity Immobilized Human PVRIG, Mouse IgG2a Fc Tag, low endotoxin at 2 μg/mL (100 μL/well) can bind Human Nectin-2, His Tag with a linear range of 0.078-0.625 μg/mL
Reconstitution Instructions Reconstitute in sterile deionized water to a concentration of 100 µg/ml.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Poliovirus receptor-related 2 (PVRL2) is also known as nectin-2 and CD112 (formerly herpesvirus entry mediator B, HVEB), which is a human plasma membrane glycoprotein. PVRL2 is one of the plasma membrane components of adherens junctions. PVRL2 also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in PVRL2 gene have been associated with differences in the severity of multiple sclerosis. Also, PVRL2 binds with low affinity to TIGIT. Furthermore, PVRL2 acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV).


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