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Human CellExp™ MMP-2,Human Recombinant

Involved in the breakdown of extracellular matrix
Catalog #: 7245
SKU-Size Size Price Qty
7245-10 10 μg
$245.00
7245-50 50 μg
$920.00
More Sizes Get Quote

Product Details

Alternate Name MMP2, Matrix metalloproteinase-2, 72 kDa type IV collagenase, 72 kDa gelatinase, Gelatinase A, TBE-1, CLG4A, EC:3.4.24.24
Gene Symbol MMP-2
Gene ID 4313
Accession # P08253
Source HEK 293 cells
Appearance Lyophilized powder
Physical Form Description Lyophilized
Molecular Weight This protein has 450 amino acids with a 6x His tag at C-terminus, and a calculated MW of 51 kDa. The N-terminal is Ala 20. The protein migrates to ~60 kDa under reducing conditions (SDS-PAGE) due to glycosylation.
Purity by SDS-PAGE ≥95%
Biological Activity Different amounts of activated MMP-2 were incubated with FRET-based substrate using BioVision’s MMP-9 Inhibitor Screening Kit (Fluorometric) (Cat. No. K844). The fluorescence (Ex/Em = 325/393 nm) was monitored over a 60 min time period.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.
Amino Acid Sequence Ala 30 – Cys 660
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Matrix metalloproteinase-2 (MMP-2) is also known as 72 kDa type IV collagenase, 72 kDa gelatinase, Gelatinase A and CLG4A, which belongs to the peptidase M10A family. MMP-2 is involved in the cleavage of gelatin type I and collagen types IV, V, VII, X. MMP-2 cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln and also cleaves KISS at a Gly-|-Leu bond. MMP-2 plays a role in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation and atherosclerotic plaque rupture. The circulating MMP-2 and MMP-9 levels may be a useful marker for the identification of patients at risk for heart failure.


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