You have no items in your shopping cart.
Product Details
| Alternate Name | MMP2, Matrix metalloproteinase-2, 72 kDa type IV collagenase, 72 kDa gelatinase, Gelatinase A, TBE-1, CLG4A, EC:3.4.24.24 |
|---|---|
| Gene Symbol | MMP-2 |
| Gene ID | 4313 |
| Accession # | P08253 |
| Source | HEK 293 cells |
| Appearance | Lyophilized powder |
| Physical Form Description | Lyophilized |
| Molecular Weight | This protein has 450 amino acids with a 6x His tag at C-terminus, and a calculated MW of 51 kDa. The N-terminal is Ala 20. The protein migrates to ~60 kDa under reducing conditions (SDS-PAGE) due to glycosylation. |
| Purity by SDS-PAGE | ≥95% |
| Biological Activity | Different amounts of activated MMP-2 were incubated with FRET-based substrate using BioVision’s MMP-9 Inhibitor Screening Kit (Fluorometric) (Cat. No. K844). The fluorescence (Ex/Em = 325/393 nm) was monitored over a 60 min time period. |
| Reconstitution Instructions | Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex. |
| Amino Acid Sequence | Ala 30 – Cys 660 |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not to be used in humans |
Details
Matrix metalloproteinase-2 (MMP-2) is also known as 72 kDa type IV collagenase, 72 kDa gelatinase, Gelatinase A and CLG4A, which belongs to the peptidase M10A family. MMP-2 is involved in the cleavage of gelatin type I and collagen types IV, V, VII, X. MMP-2 cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln and also cleaves KISS at a Gly-|-Leu bond. MMP-2 plays a role in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation and atherosclerotic plaque rupture. The circulating MMP-2 and MMP-9 levels may be a useful marker for the identification of patients at risk for heart failure.
Why buy BioVision Products?
 |
 |
 |
 |
Innovation |
Affordability |
Global Presence |
Technical Support |
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways. |
BioVision is committed to providing the highest quality products at a competitive price. |
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery. |
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently. |
