Human CellExp™ MMP-2,Human Recombinant

Involved in the breakdown of extracellular matrix
Catalog #: 7245 | abID: ab285783

Product Details

abID ab285783
Alternate Name MMP2, Matrix metalloproteinase-2, 72 kDa type IV collagenase, 72 kDa gelatinase, Gelatinase A, TBE-1, CLG4A, EC:
Gene Symbol MMP-2
Gene ID 4313
Accession # P08253
Source HEK 293 cells
Appearance Lyophilized powder
Physical Form Description Lyophilized
Molecular Weight This protein has 450 amino acids with a 6x His tag at C-terminus, and a calculated MW of 51 kDa. The N-terminal is Ala 20. The protein migrates to ~60 kDa under reducing conditions (SDS-PAGE) due to glycosylation.
Purity by SDS-PAGE ≥95%
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.
Amino Acid Sequence Ala 30 – Cys 660
Specific Activity > 2 mU/mg
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans


Matrix metalloproteinase-2 (MMP-2) is also known as 72 kDa type IV collagenase, 72 kDa gelatinase, Gelatinase A and CLG4A, which belongs to the peptidase M10A family. MMP-2 is involved in the cleavage of gelatin type I and collagen types IV, V, VII, X. MMP-2 cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln and also cleaves KISS at a Gly-|-Leu bond. MMP-2 plays a role in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation and atherosclerotic plaque rupture. The circulating MMP-2 and MMP-9 levels may be a useful marker for the identification of patients at risk for heart failure.

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