Product Details
| abID | ab285783 |
|---|---|
| Alternate Name | MMP2, Matrix metalloproteinase-2, 72 kDa type IV collagenase, 72 kDa gelatinase, Gelatinase A, TBE-1, CLG4A, EC:3.4.24.24 |
| Gene Symbol | MMP-2 |
| Gene ID | 4313 |
| Accession # | P08253 |
| Source | HEK 293 cells |
| Appearance | Lyophilized powder |
| Physical Form Description | Lyophilized |
| Molecular Weight | This protein has 450 amino acids with a 6x His tag at C-terminus, and a calculated MW of 51 kDa. The N-terminal is Ala 20. The protein migrates to ~60 kDa under reducing conditions (SDS-PAGE) due to glycosylation. |
| Purity by SDS-PAGE | ≥95% |
| Reconstitution Instructions | Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex. |
| Amino Acid Sequence | Ala 30 – Cys 660 |
| Specific Activity | > 2 mU/mg |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not to be used in humans |
Details
Matrix metalloproteinase-2 (MMP-2) is also known as 72 kDa type IV collagenase, 72 kDa gelatinase, Gelatinase A and CLG4A, which belongs to the peptidase M10A family. MMP-2 is involved in the cleavage of gelatin type I and collagen types IV, V, VII, X. MMP-2 cleaves the collagen-like sequence Pro-Gln-Gly-|-Ile-Ala-Gly-Gln and also cleaves KISS at a Gly-|-Leu bond. MMP-2 plays a role in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation and atherosclerotic plaque rupture. The circulating MMP-2 and MMP-9 levels may be a useful marker for the identification of patients at risk for heart failure.
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