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Human CellExp™ MMP-13, Human Recombinant

A Protein involved in breakdown of extracellular matrix
Catalog #: P1566
$275.00

Product Details

Cat # +Size P1566-10
Size 10 μg
Alternate Name Collagenase 3, Matrix metalloproteinase-13, CLG 3, CLG3EC, EC 3.4.24.22
Gene Symbol MMP13
Gene ID 4322
Accession # P45452
Source HEK 293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered PBS (pH 7.4) with 5% trehalose
Molecular Weight 53 kDa (6xHis tag at the C-terminus)
Purity by SDS-PAGE >95%
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.
Amino Acid Sequence Leu 20 – Cys 471
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

MMP13 or collagenase 3 is an endopeptidase that is part of the calcium and zinc dependent matrix metalloproteinase family. Like most MMPs, it is secreted as an inactive pro-form and is activated once its pro-domain is cleaved. Additionally, MMP13 is expressed by fibroblasts, chondrocytes, and squamous epithelial cells. MMP-13 (Collagenase-3) has been demonstrated to degrade a range of extracellular matrix proteins, including collagen types I, II, III, IV, IX, X and XIV, gelatin, aggrecan, perlecan and fibronectin. Furthermore, it is involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis.


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