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Human CellExp™ Lipocalin-2 / LCN2, mouse recombinant

Functions as a growth factor and is upregulated during inflammation
Catalog #: 7568
SKU-Size Size Price Qty
7568-10 10 μg
$240.00
7568-50 50 μg
$750.00
More Sizes Get Quote

Product Details

Alternate Name NGAL, LCN2, Lipocalin-2, 24p3, MSFI, Siderocalin; Oncogene 24p3; Neutrophil Gelatinase-associated Lipocalin; NGAL.
Gene Symbol LCN2
Gene ID 16819
Accession # P11672
Source HEK293 cells
Appearance Liquid
Physical Form Description 0.2 μm-filtered solution in PBS
Molecular Weight ~25.0 kDa (monomer). Mouse lipocalin-2 (aa 1-200) is fused at the C-terminus to a FLAG®-tag.
Purity by SDS-PAGE ≥90%
Endotoxin Level <0.1 EU/μg by LAL method
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Lipocalin-2 (LCN2), also known as oncogene 24p3 or neutrophil gelatinase-associated lipocalin (NGAL), MSFI, The binding of lipocalin-2 to bacterial siderophores is important in the innate immune response to bacterial infection. Upon encountering invading bacteria the toll-like receptors on immune cells stimulate the synthesis and secretion of lipocalin-2. Secreted lipocalin-2 then limits bacterial growth by sequestering iron-containing siderophores. Lipocalin-2 also functions as a growth factor. LCN2 is strongly upregulated during inflammation and is upregulated by interleukin 1 (but not TNF alpha) in humans. There are indications that some forms of acne could be caused due to the gene not being transcribed, and that Isotretinoin corrects this. NFAT3 (NFATc4) NFAT by blocking the expression of LCN2 inhibits breast carcinoma cell motility. Recent studies have revealed that NGAL plays an important role in the physiopathology of chronic myeloid leukaemia (CML) mediated by BCR-ABL.


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