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Human CellExp™ LEFTY-I, Human Recombinant

Plays a role in left-right asymmetry determination of organ systems during development
Catalog #: 4873
SKU-Size Size Price Qty
4873-10 10 μg
$325.00
4873-50 50 μg
$1,250.00
More Sizes Get Quote

Product Details

Alternate Name Left-right determination factor 1, Left-right determination factor B, Protein lefty-1, Protein lefty-B
Gene Symbol LEFTY1
Gene ID 10637
Accession # O75610
Source Human 293 cells
Appearance Lyophilized protein
Physical Form Description Lyophilized in 10 mM Tris-HCl, pH 7.4, 50 mM NaCl, 0.5% CHAPS.
Molecular Weight 38 kDa
Purity by SDS-PAGE ≥90%
Endotoxin Level <0.1 ng/μg
Biological Activity The specific activity was determined by dose dependent ability to inhibit BMP-4 (6.5 ng/mL) induction of alkaline phosphatase production in the MC-3T3-E1 cell line (Mouse Chondrogenic cell line).
Reconstitution Instructions Reconstitute in sterile water.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
USAGE For Research Use Only! Not to be used in humans

Details

BioVision’s LEFTY-1 is expressed in human 293 cells as a monomeric glycoprotein with an apparent molecular mass of 38 kDa. This cytokine is produced in a human cell expression system with serum-free, chemically defined media. Production in human 293 cells offers authentic glycosylation, contributing to stability in cell growth media. Lefty proteins function as an antagonist of the Nodal Signaling pathway. Proper functioning of Lefty is crucial to the proper development of the heart, lungs, spleen, and liver.


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