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Human CellExp™ LAIR1 / CD305, Fc Tag, Mouse Recombinant

Negative regulator of NK cells, B cells and T cells
Catalog #: P1408
SKU-Size Size Price Qty
P1408-10 10 µg
$105.00
P1408-50 50 µg
$395.00
More Sizes Get Quote

Product Details

Alternate Name LAIR1, CD305
Gene Symbol Lair1
Gene ID 52855
Accession # Q8BG84-1
Source HEK 293 cells
Appearance Lyophilized powder
Physical Form Description Lyophilized protein
Molecular Weight This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 40.6 kDa. The protein migrates as 50-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity by SDS-PAGE >95%
Endotoxin Level Less than 0.1 EU per μg by the LAL method.
Reconstitution Instructions Reconstitute in sterile deionized water to a desired concentration.
Amino Acid Sequence AA Gln 22 - Tyr 141
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 or CD305 is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell–mediated cytotoxicity. Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.Diseases associated with LAIR1 include Chronic Active Epstein-Barr Virus Infection and Palindromic Rheumatism.


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