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Human CellExp™ LAIR1 / CD305, Fc Tag, Human Recombinant

Negative regulator of NK cells, B cells and T cells
Catalog #: P1239

In stock

SKU-Size Size Price Qty
P1239-10 10 μg
$105.00
P1239-50 50 μg
$365.00

Product Details

Alternate Name LAIR1, CD305
Gene Symbol LAIR1
Gene ID 3903
Accession # Q6GTX8
Source HEK 293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH 7.5. Normally trehalose is added as protectant before lyophilization.
Molecular Weight 42.1 kDa
Purity by SDS-PAGE > 95%
Endotoxin Level < 1.0 EU per/μg
Reconstitution Instructions Reconstitute in sterile deionized water to a concentration of 50 µg/ml.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 or CD305 is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell–mediated cytotoxicity. Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.Diseases associated with LAIR1 include Chronic Active Epstein-Barr Virus Infection and Palindromic Rheumatism.


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