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Human CellExp™ Insulin R / CD220, Human Recombinant

Receptor tyrosine kinase which mediates the pleiotropic actions of insulin.
Catalog #: P1377

In stock

SKU-Size Size Price Qty
P1377-10 10 µg
$95.00
P1377-50 50 µg
$355.00
More Sizes Get Quote

Product Details

Alternate Name INSR, Insulin receptor, IR, CD220
Gene Symbol IRS1
Gene ID 3667
Accession # P06213-2
Source HEK 293 cells
Appearance Lyophilized powder
Physical Form Description Lyophilized
Molecular Weight 106.5 kDa (His 28 - Lys 944)
Purity by SDS-PAGE >90% as determined by SDS-PAGE
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile deionized water, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. It is recommended to store at -20°C.
Amino Acid Sequence AA His 28 - Lys 944
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Insulin receptor (INSR) is also known as CD antigen CD220, which can be cleaved into the following 2 chains: Insulin receptor subunit alpha and Insulin receptor subunit beta. INSR is a tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains carry the insulin-binding regions, while the beta chains carry the kinase domain. Forms a hybrid receptor with IGF1R, the hybrid is a tetramer consisting of 1 alpha chain and 1 beta chain of INSR and 1 alpha chain and 1 beta chain of IGF1R. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). Isoform Short of INSR has a higher affinity for IGFII binding. When present in a hybrid receptor with IGF1R, INSR binds IGF1.


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