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Product Details
| Alternate Name | CD218 antigen-like family member A; CD218a; IL1R RP; IL18RA; Interleukin 18 receptor 1; CDw218a; IL-1Rrp |
|---|---|
| Gene Symbol | IL18R1/CD218a |
| Gene ID | 8809 |
| Accession # | NP_003846.1; Q13478 |
| Source | HEK293 |
| Appearance | Sterile Filtered colorless solution |
| Physical Form Description | Solid |
| Molecular Weight | 80-105 kDa |
| Purity by SDS-PAGE | ≥ 85% |
| Biological Activity | Measured by its ability to inhibit the IL-18-induced response of KG-1 human acute myelogenous leukemia cells in the presence of soluble Recombinant Human IL-18 R beta /IL-1 R7 Fc Chimera. Approximately 5-15 μg/mL of rhIL-18 Ra/Fc will inhibit 50% of the b |
| Reconstitution Instructions | Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. |
| Amino Acid Sequence | Glu20-Arg329 aa |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Interleukin-18 receptor 1 (IL18R1) is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is also known as CD218. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IL18R1 is found expressed in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from brain, skeletal muscle, pancreas, and kidney. High level of expression is found in Hodgkin disease cell lines. IL18R1 contains 3 Ig-like C2-type (immunoglobulin-like) domains and 1 TIR domain. It is a single-pass type I membrane protein. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. The increased expression of IL18R1 may contribute pathogenically to disease and is therefore a potential therapeutic target.
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