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Human CellExp™ IL18R1/CD218a Protein, Human recombinant

IL18 mediated signal transductor
Catalog #: P1640
SKU-Size Size Price Qty
P1640-20 20 μg
$265.00
P1640-50 50 μg
$345.00
More Sizes Get Quote

Product Details

Alternate Name CD218 antigen-like family member A; CD218a; IL1R RP; IL18RA; Interleukin 18 receptor 1; CDw218a; IL-1Rrp
Gene Symbol IL18R1/CD218a
Gene ID 8809
Accession # NP_003846.1; Q13478
Source HEK293
Appearance Sterile Filtered colorless solution
Physical Form Description Solid
Molecular Weight 80-105 kDa
Purity by SDS-PAGE ≥ 85%
Biological Activity Measured by its ability to inhibit the IL-18-induced response of KG-1 human acute myelogenous leukemia cells in the presence of soluble Recombinant Human IL-18 R beta /IL-1 R7 Fc Chimera. Approximately 5-15 μg/mL of rhIL-18 Ra/Fc will inhibit 50% of the b
Reconstitution Instructions Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.
Amino Acid Sequence Glu20-Arg329 aa
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Interleukin-18 receptor 1 (IL18R1) is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein is also known as CD218. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This receptor specifically binds interleukin 18 (IL18), and is essential for IL18 mediated signal transduction. IL18R1 is found expressed in lung, leukocytes, spleen, liver, thymus, prostate, small intestine, colon, placenta, and heart, and is absent from brain, skeletal muscle, pancreas, and kidney. High level of expression is found in Hodgkin disease cell lines. IL18R1 contains 3 Ig-like C2-type (immunoglobulin-like) domains and 1 TIR domain. It is a single-pass type I membrane protein. This gene along with four other members of the interleukin 1 receptor family, including IL1R2, IL1R1, ILRL2 (IL-1Rrp2), and IL1RL1 (T1/ST2), form a gene cluster on chromosome 2q. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. The increased expression of IL18R1 may contribute pathogenically to disease and is therefore a potential therapeutic target.


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