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Human CellExp™ IL-5, Human Recombinant

Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells.
Catalog #: P1486
SKU-Size Size Price Qty
P1486-10 10 µg
$145.00
P1486-50 50 µg
$475.00
More Sizes Get Quote

Product Details

Gene Symbol IL5
Gene ID 3567
Accession # P05113
Source HEK 293 cells
Appearance Lyophilized powder
Physical Form Description Lyophilized
Molecular Weight 14 kDa with a 6×His tag at the N-terminus
Purity by >95%
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.
Amino Acid Sequence Ile 20 – Ser 134
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Interleukin-5 (IL-5) is identified by its ability to support the growth and terminal differentiation of mouse B cells to immunoglobulin secreting cells. IL-5 also exerts pleiotropic activities on various target cells including eosinophils and basophils via receptors of IL-5-specific α and common β-subunit. IL-5’s stimulation of eosinophil has been implicated in the pathogenesis of allergic inflammatory diseases, such as asthma. Targeting the interleukin-5 pathway offers benefit to patients with severe asthma. Mepolizumab is an anti-interleukin-5 (IL-5) humanized monoclonal antibody that has been approved as an add-on biological treatment for severe eosinophilic asthma, by both the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA).


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