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Human CellExp™ IL-4, Human Recombinant

A key regulator in humoral and adaptive immunity
Catalog #: 6463
SKU-Size Size Price Qty
6463-10 10 μg
$305.00
6463-50 50 μg
$1,180.00
More Sizes Get Quote

Product Details

Alternate Name BCGF, BCDF, B cell stimulating factor, BSF-1, Lymphocyte stimulatory factor 1, IL-4, MGC79402, Binetrakin, Pitrakinra.
Gene Symbol IL4
Gene ID 3565
Accession # P05112
Source Human 293 cell expressed
Appearance Lyophilized
Physical Form Description Lyophilized from a solution of 20 mM Tris-HCl, pH 7.4, with 300 mM NaCl.
Molecular Weight 14 and 19 kDa, monomer
Purity by SDS-PAGE ≥95%
Endotoxin Level < 1.0 EU per 1 μg of protein
Biological Activity ED₅₀ is typically 0.1 to 0.5 ng/mL. The specific activity was determined by the dose-dependent simulation of the proliferation of human TF-1 cells (human erythroleukemic indicator cell line).
Reconstitution Instructions Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

IL4 is a pleiotropic cytokine and a potent lymphoid cell growth factor that stimulates the growth and survivability of certain B cells and T cells. It is produced by activated T cells and is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.


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