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Human CellExp™ IL-23, Human Recombinant

A T cell-stimulating factor
Catalog #: 6470
SKU-Size Size Price Qty
6470-10 10 µg
$395.00
6470-50 50 µg
$1,500.00
More Sizes Get Quote

Product Details

Alternate Name Interleukin 23 alpha subunit p19, Interleukin-12 subunit beta p40, SGRF, IL23P19, IL-23-A, interleukin-six, G-CSF related factor, JKA3 induced upon T-cell activation, interleukin 12B (natural killer cell stimulatory factor 2 cytotoxic lymphocyte maturatio
Gene Symbol IL23A
Gene ID 51561
Accession # Q9NPF7
Source Human 293 cell expressed
Appearance Lyophilized
Physical Form Description Lyophilized in PBS.
Molecular Weight 55 kDa, heterodimer, glycosylated
Purity by SDS-PAGE > 95%
Endotoxin Level < 1.0 EU per 1 μg of protein
Biological Activity ED₅₀ is typically 2 to 20 ng/mL. The specific activity was determined by the dose-dependent secretion of h-IFN-gamma from human PBMC.
Reconstitution Instructions Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

IL23 is composed of a subunit of the heterodimeric cytokine IL23 and the p40 subunit of interleukin 12 (IL12B). Interleukin-23 (IL-23) belongs to the IL-12 family and is produced by antigen presenting cells. IL-23 using IL12RB1 and IL-23R (specific for IL-23) can activate STAT and NF-kB pathways and stimulate the production of interferon-gamma. ). IL-23 is known to take a vital part in the inflammation process and is associated with auto immune diseases. However, unlike IL12, which acts primarily on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells.


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