Product Details
| Alternate Name | Soluble IL-2 receptor; TAC-antigen; CD25 antigen; CD25; Interleukin-2 receptor subunit alpha |
|---|---|
| Gene ID | 3559 |
| Accession # | P01589 |
| Source | HEK 293 cells |
| Appearance | Lyophilized protein |
| Physical Form Description | Lyophilized powder |
| Molecular Weight | 42 kDa (observed) |
| Purity by SDS-PAGE | > 95% |
| Formulation | Lyophilized after dialysis against PBS |
| Endotoxin Level | < 0.2 EU/μg as determined by LAL method |
| Reconstitution Instructions | Reconstitute in sterile deionized water or PBS at 100 μg/ml. |
| Amino Acid Sequence | HHHHHHHHEL CDDDPPEIPH ATFKAMAYKE GTMLNCECKR GFRRIKSGSL YMLCTGNSSH SSWDNQCQCT SSATRNTTKQ VTPQPEEQKE RKTTEMQSPM QPVDQASLPG HCREPPPWEN EATERIYHFV VGQMVYYQCV QGYRALHRGP AESVCKMTHG KTRWTQPQLI CTGEMETSQF PGEEKPQASP EGRPESETSC |
| Specific Activity | Determined by its ability to increase the proliferation effect of IL-2 in murine CTLL-2 cells. In the presence of 1 ng/ml of recombinant IL-2, ED50 for this effect is < 1.5 µg/ml. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -70°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Interleukin-2 receptor (IL-2R) is a heterotrimeric protein expressed on the surface of certain immune cells, such as lymphocytes, that binds and responds to the cytokine IL-2. The IL-2R is made up of 3 subunits - alpha (α), beta (β) and gamma (γ). The α and β chains are involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the γ-chain, along with the β subunit. The β and γ chains of the IL-2R are members of the type I cytokine receptor family. IL-2R has a high binding affinity to IL-2 and is expressed by antigen-activated T lymphocytes (T cells). IL-2 Rα is also known as CD25, p55, and Tac (activated T cell) antigen.
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