Product Details
| Alternate Name | T-cell growth factor (TCGF), Aldesleukin, Lymphokine, IL-2. |
|---|---|
| Gene Symbol | IL2 |
| Gene ID | 3558 |
| Accession # | P60568 |
| Source | Human 293 cell expressed |
| Appearance | Lyophilized |
| Physical Form Description | Lyophilized from a PBS solution. |
| Molecular Weight | 15 kDa, monomer, glycosylated |
| Purity by SDS-PAGE | ≥95% |
| Biological Activity | ED₅is typically 0.2 to 2 ng/mL. The specific activity was determined by the dose-dependent stimulation of the proliferation of mouse CTLL-2 cells (mouse cytotoxic T cell line). |
| Reconstitution Instructions | Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not to be used in humans |
Details
IL-2 is a potent immuno-modulator, which mediates a wide range of immune and inflammatory responses and is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.
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