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Human CellExp™ IL-2, Human Recombinant

A regulator of lymphocyte activities
Catalog #: 6461
SKU-Size Size Price Qty
6461-10 10 μg
$190.00
6461-50 50 μg
$645.00
More Sizes Get Quote

Product Details

Alternate Name T-cell growth factor (TCGF), Aldesleukin, Lymphokine, IL-2.
Gene Symbol IL2
Gene ID 3558
Accession # P60568
Source Human 293 cell expressed
Appearance Lyophilized
Physical Form Description Lyophilized from a PBS solution.
Molecular Weight 15 kDa, monomer, glycosylated
Purity by SDS-PAGE ≥95%
Endotoxin Level < 1.0 EU per 1 μg of protein
Biological Activity ED₅is typically 0.2 to 2 ng/mL. The specific activity was determined by the dose-dependent stimulation of the proliferation of mouse CTLL-2 cells (mouse cytotoxic T cell line).
Reconstitution Instructions Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

IL-2 is a potent immuno-modulator, which mediates a wide range of immune and inflammatory responses and is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.


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