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Human CellExp™ IL-2, Human Recombinant

A regulator of lymphocyte activities
Catalog #: P1369

In stock

SKU-Size Size Price Qty
P1369-10 10 µg
$95.00
P1369-50 50 µg
$245.00
More Sizes Get Quote

Product Details

Alternate Name IL2, TCGF, lymphokine, Interleukin 2
Gene Symbol IL2
Gene ID 3558
Accession # P60568
Source HEK 293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered solution in PBS, pH5.0. Normally trehalose is added as protectant before lyophilization.
Molecular Weight 17 kDa
Purity by SDS-PAGE ≥95%
Endotoxin Level < 1.0 EU per 1 μg of protein
Biological Activity Human IL-2 stimulates proliferation of CTLL-2 cells. The ED50 for this effect is 0.284-0.355 ng/ml
Reconstitution Instructions Reconstitute in sterile deionized water to a concentration of 100 µg/ml.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Interleukin-2 (IL-2) is an interleukin, a type of cytokine immune system signaling molecule, which is a leukocytotrophic hormone that is instrumental in the body's natural response to microbial infection and in discriminating between foreign (non-self) and self. IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes, the cells that are responsible for immunity. Mature human IL-2 shares 56% and 66% aa sequence identity with mouse and rat IL-2, respectively. Human and mouse IL-2 exhibit crossspecies activity. The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes. IL-2 is also necessary during T cell development in the thymus for the maturation of a unique subset of T cells that are termed regulatory T cells (T-regs). After exiting from the thymus, T-Regs function to prevent other T cells from recognizing and reacting against "self antigens", which could result in "autoimmunity". T-Regs do so by preventing the responding cells from producing IL-2. Thus, IL-2 is required to discriminate between self and non-self, another one of the unique characteristics of the immune system.


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