Product Details
| Alternate Name | IL17A/F, IL17 A/F, IL-17A/F, IL-17 A/F, IL17AF, IL-17 AF, Interleukin-17 A/F, Interleukin-17 AF. |
|---|---|
| Gene Symbol | IL17F |
| Gene ID | 112744 |
| Accession # | Q96PD4 |
| Source | Human 293 cell expressed |
| Appearance | Lyophilized |
| Physical Form Description | Lyophilized in PBS. |
| Molecular Weight | 38 kDa, homodimer, glycosylated |
| Purity by SDS-PAGE | > 95% |
| Endotoxin Level | < 1.0 EU per 1 μg of protein |
| Biological Activity | ED₅₀ is typically 100 to 500 ng/mL. The specific activity was determined by the dose-dependent induction of IL-6 secretion from NHDF Adult fibroblasts. |
| Reconstitution Instructions | Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not to be used in humans |
Details
Interleukin-17 is a proinflammatory cytokine produced by activated T cells. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. IL17 can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. IL-17F is a member of the IL-17 family of structurally-related cytokines. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17F stimulates proliferation and activation of T-cells and PBMCs. IL-17F also regulates cartilage matrix turnover and inhibits angiogenesis.
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