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Human CellExp™ IL-17F, Human Recombinant

A proinflammatory cytokine produced by activated T cells
Catalog #: 6469
SKU-Size Size Price Qty
6469-10 10 µg
$135.00
6469-50 50 µg
$540.00
More Sizes Get Quote

Product Details

Alternate Name IL17A/F, IL17 A/F, IL-17A/F, IL-17 A/F, IL17AF, IL-17 AF, Interleukin-17 A/F, Interleukin-17 AF.
Gene Symbol IL17F
Gene ID 112744
Accession # Q96PD4
Source Human 293 cell expressed
Appearance Lyophilized
Physical Form Description Lyophilized in PBS.
Molecular Weight 38 kDa, homodimer, glycosylated
Purity by SDS-PAGE > 95%
Endotoxin Level < 1.0 EU per 1 μg of protein
Biological Activity ED₅₀ is typically 100 to 500 ng/mL. The specific activity was determined by the dose-dependent induction of IL-6 secretion from NHDF Adult fibroblasts.
Reconstitution Instructions Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Interleukin-17 is a proinflammatory cytokine produced by activated T cells. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. IL17 can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. IL-17F is a member of the IL-17 family of structurally-related cytokines. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17F stimulates proliferation and activation of T-cells and PBMCs. IL-17F also regulates cartilage matrix turnover and inhibits angiogenesis.


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