Product Details
| Alternate Name | CTLA-8, IL-17, IL-17A, Cytotoxic T-lymphocyte-associated antigen 8. |
|---|---|
| Gene Symbol | IL17A |
| Gene ID | 3605 |
| Accession # | Q16552 |
| Source | Human 293 cell expressed |
| Appearance | Lyophilized |
| Physical Form Description | Lyophilized in 10 mM Tris, pH 7.4 and 250 mM NaCl. |
| Molecular Weight | 30 to 35 kDa, homodimer, glycosylated |
| Purity by SDS-PAGE | > 95% |
| Endotoxin Level | < 1.0 EU per 1 μg of protein |
| Biological Activity | ED₅₀ is typically 5 to 25 ng/mL. The specific activity was determined by the dose-dependent induction of IL-6 secretion from NDHF Adult fibroblasts. |
| Reconstitution Instructions | Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not to be used in humans |
Details
Interleukin-17 is a proinflammatory cytokine produced by activated T cells. IL-17 regulates the activities of NF-kappa B and mitogen-activated protein kinases. IL17 can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The original described IL-17 protein, now known as IL-17A, was identified from a CD4+ T cells DNA library. IL-17 can be induced from primary peripheral blood CD4+ T cells upon stimulation. Supernatant from cells transfected with IL-17 induced IL-16 and IL-18 production and enhanced the surface expression of the intracellular adhesion molecule-1 (ICAM-1) in human fibroblasts.
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