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Human CellExp™ IL-13, Human Recombinant

A mediator of allergic inflammation and disease
Catalog #: P1186
$195.00

Product Details

Cat # +Size P1186-10
Size 10 μg
Alternate Name IL13, ALRH, BHR1, MGC116786, MGC116788, MGC116789, P600, Interleukin-13
Gene Symbol IL13
Gene ID 3596
Accession # P35225
Source HEK293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered solution in PBS pH 7.4. Generally 5-8% Mannitol or Trehalose is added as a protectant before lyophilization.
Molecular Weight 13.4 kDa
Purity by SDS-PAGE > 92%
Endotoxin Level < 1.0 EU per/μg
Biological Activity Immobilized Human IL-13, Tag Free at 10 μg/mL (100 μL/well) can bind Anti-IL13 MAb, Human IgG4 with a linear range of 0.5-8 ng/mL.
Reconstitution Instructions Reconstitute in sterile deionized water to the desired protein concentration.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Interleukin 13 (IL13) is also known as ALRH, BHR1and P600, is a single-chain glycosylated polypeptide, and is a cytokine critical in regulating inflammatory and immune responses. IL13 is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains. The functions of IL-13 overlap considerably with those of IL-4, especially with regard to changes induced on hematopoietic cells, but these effects are probably less important given the more potent role of IL-4. IL-13 induces matrix metalloproteinases (MMPs) as part of a mechanism that protects against excessive allergic inflammation that predisposes to asphyxiation. IL-13 induces many features of allergic lung disease, including airway hyperresponsiveness, goblet cell metaplasia and mucus hypersecretion, which all contribute to airway obstruction.


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