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Human CellExp™ IL-12B & IL-12A Heterodimer, Human Recombinant

T cell-stimulating factor
Catalog #: P1178
$530.00

Product Details

Cat # +Size P1178-20
Size 20 μg
Alternate Name IL12, p70, Interleukin-12
Gene Symbol IL12B, IL12A
Gene ID 3593, 3592
Accession # P29460, P29459
Source HEK293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered solution in PBS pH 7.4. Generally 5-8% Mannitol or Trehalose is added as a protectant before lyophilization.
Molecular Weight 36.6 kDa, 23.8 kDa
Purity by SDS-PAGE > 95%
Endotoxin Level < 1.0 EU per/μg
Reconstitution Instructions Reconstitute in sterile deionized water to the desired protein concentration.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Interleukin 12 (IL12) is also known as p70, and is an interleukin that is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation.IL12 is a heterodimeric cytokine, containing IL-12A (p35) and IL-12B (p40). IL-12 is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of IFN-γ and TNF-α from T cells and NK cells, and reduces IL-4 mediated suppression of IFN-γ. IL-12 plays an important role in the activities of natural killer cells and T lymphocytes. IL-12 also has anti-angiogenic activity, which means it can block the formation of new blood vessels.


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