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Human CellExp™ IL-12 R beta 1 / CD212, Fc Tag, Human Recombinant

Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction.
Catalog #: P1458
SKU-Size Size Price Qty
P1458-10 10 µg
$105.00
P1458-50 50 µg
$395.00
More Sizes Get Quote

Product Details

Alternate Name IL-12 R beta 1, IL12RB1, CD212, IL12R, IL12RB, IL-12RB1
Gene Symbol IL12RB1
Gene ID 3594
Accession # P42701
Source HEK 293 cells
Appearance Lyophilized
Physical Form Description Lyophilized
Molecular Weight This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 83.5 kDa. The protein migrates as 90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity by SDS-PAGE >95%
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Reconstitution Instructions Reconstitute in sterile deionized water to the desired protein concentration.
Amino Acid Sequence Cys 24 - Glu 540
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The human IL-12 R subunit is a member of the cytokine receptor superfamily and the functional high-affinity IL-12R is composed of at least two beta-type cytokine receptor subunits, each independently exhibiting a low affinity for IL-12. IL-12 R beta 1 (Interleukin-12 receptor subunit beta-1) is also known as IL-12RB1, CD212. Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.


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