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Human CellExp™ IL-12, Human Recombinant

A T cell-stimulating factor
Catalog #: 6467
SKU-Size Size Price Qty
6467-10 10 µg
$270.00
6467-50 50 µg
$1,180.00
More Sizes Get Quote

Product Details

Alternate Name NKSF, CTL maturation factor (TCMF), Cytotoxic lymphocyte maturation factor (CLMF), TSF, Edodekin-alpha, IL-12.
Gene Symbol IL12A
Gene ID 3592
Accession # P29459
Source Human 293 cell expressed
Appearance Lyophilized
Physical Form Description Lyophilized from a PBS solution.
Molecular Weight 57 kDa, heterodimer, glycosylated
Purity by SDS-PAGE > 95%
Endotoxin Level < 1.0 EU per 1 μg of protein
Biological Activity ED₅₀ is typically 0.1 to 0.5 ng/mL ng/mL. The specific activity was determined by the dose-dependent release of IFN-gamma from the human NK92 cell line in presence of 20 ng/mL rIL-2.
Reconstitution Instructions Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

IL-12 is a potent regulator of cell mediated immune responses and in induces IFN-Ɣ production by NK and T cells. It is produced by activated monocytes/macrophage cells, B-lymphocytes, and connective tissue type mast cells. Among its biological activities, IL-12 promotes the growth and activity of activated NK, CD4+, and CD8+ cells and induce the development of IFN-Ɣ producing Th1 cells.


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