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Human CellExp™ IL-10, Human Recombinant

An anti-inflammatory cytokine
Catalog #: 6466
SKU-Size Size Price Qty
6466-10 10 µg
$270.00
6466-50 50 µg
$1,180.00
More Sizes Get Quote

Product Details

Alternate Name B-TCGF, CSIF, TGIF, IL-10, IL10A, MGC126450, MGC126451, Cytokine synthesis inhibitory factor.
Gene Symbol IL10
Gene ID 3586
Accession # P22301
Source HEK 293 cells
Appearance Lyophilized
Physical Form Description Lyophilized
Molecular Weight 19 kDa with a 6×His tag at the C-terminus
Purity by SDS-PAGE > 95%
Endotoxin Level < 1.0 EU per 1 μg of protein
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.
Amino Acid Sequence Ser 19 – Asn 178
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

The cytokine IL-10 is a key anti-inflammatory mediator with an essential role in the development and proliferation of regulatory T cells, restricting myeloid and chronic inflammatory T cell responses. It has been shown that in solution IL-10 predominantly exists as a homodimer. However, the subunits within the dimer are non-covalently associated, although each subunit contains two intra-chain disulfide bonds. IL10 binds to its hetero-tetrameric receptor comprising IL10RA and IL10RB, which activates multiple pathways that contribute to the downstream anti-inflammatory effects. It also plays important roles in other processes such as sterile wound healing, autoimmunity, cancer, and homeostasis. Given the wide spectrum of the anti-inflammatory properties attributed to IL-10, both IL-10 enhancing and blockade strategies have been tried in a number of diseases and cancer therapy.


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