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Human CellExp™ ICOS / CD278, Human recombinant

Inducible T-cell costimulator
Catalog #: 9238

In stock

SKU-Size Size Price Qty
9238-10 10 µg
$150.00
9238-100 100 µg
$590.00
More Sizes Get Quote

Product Details

Alternate Name ICOS, CD278, AILIM
Gene Symbol CD278
Gene ID 29851
Accession # NP_036224
Source HEK 293 cells
Appearance Lyophilized
Physical Form Description Lyophilized
Molecular Weight This protein is fused with a Fc tag at C-terminus and has a calculated MW of 40.4 kDa.
Endotoxin Level < 1 EU/μg
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized Human B7-H2, His Tag at 3μg/ml (100 µl/well), can bind Human ICOS, Fc Tag with a linear of 0.5-5 ng/ml.
Reconstitution Instructions Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/ml
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. CD278 / ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes.


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