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Human CellExp™ ICOS / CD278, Fc Tag, Human recombinant

Inducible T-cell costimulator
Catalog #: P1378

In stock

SKU-Size Size Price Qty
P1378-10 10 µg
$95.00
P1378-50 50 µg
$405.00
More Sizes Get Quote

Product Details

Alternate Name ICOS, CD278, AILIM, Inducible T-cell costimulator
Gene Symbol CD278
Gene ID 29851
Accession # NP_036224
Source HEK 293 cells
Appearance Lyophilized powder
Physical Form Description Lyophilized
Molecular Weight This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40.2 kDa. The protein migrates as 46-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Purity by SDS-PAGE >95% as determined by SDS-PAGE.
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile deionized water to a concentration of 100 µg/ml. Do not vortex. It is recommended to store at -20°C.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Inducible T-cell costimulator (ICOS) is also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM), CD278, which belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. ICOS enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. CD278 / ICOS prevents the apoptosis of pre-activated T-cells and also plays a critical role in CD40-mediated class switching of immunoglobin isotypes.


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