Human CellExp™ Human CD40/ TNFRSF5, Human recombinant

Tumor necrosis factor receptor superfamily member 5
Catalog #: 9230 | abID:

Product Details

Alternate Name CD40, Bp50, CDW40, MGC9013, TNFRSF5, p50
Gene Symbol CD40
Gene ID 958
Accession # AAH12419.1
Source HEK 293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
Molecular Weight This protein is fused with a 6× His tag at C-terminus and has a calculated MW of 20 kDa. The protein migrates as 32 kDa in SDS-PAGE due to glycosylation.
Purity by SDS-PAGE >95%
Purity by >95%
Endotoxin Level < 1 EU/μg
Biological Activity Immobilized Human CD40, His Tag at 1 µg/mL (100 µL/well) can bind Human CD40 Ligand /TNFSF5 with a linear range of 0.01-0.12 ng/mL.
Reconstitution Instructions Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/ml
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans


Tumor necrosis factor receptor superfamily member 5 (TNFRSF5) is also known as CD40, is a member of the TNF receptor superfamily. The expression of CD40 is diverse. TNFRSF5 has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 is the receptor for TNFSF5/CD40LG. Defects in CD40 are the cause of immunodeficiency with hyper-IgM type 3 (HIGM3).

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