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Product Details
| Alternate Name | Human Growth Hormone, GH1, GH, GHN, GH-N, hGH-N, Pituitary growth hormone, Growth hormone 1, Somatotropin. |
|---|---|
| Gene Symbol | GH1 |
| Gene ID | 2688 |
| Accession # | P01241 |
| Source | Human 293 cell expressed |
| Appearance | Lyophilized |
| Physical Form Description | Lyophilized from a TBS solution. |
| Molecular Weight | 22 kDa, monomer, non-glycosylated |
| Purity by SDS-PAGE | ≥95% |
| Endotoxin Level | < 1.0 EU per 1 μg of protein |
| Biological Activity | ED₅₀ is typically 0.4 to 2 ng/mL. The activity was determined by the dose-dependent stimulation of the proliferation of rat lymphoma line Nb2-11 cells (prolactin indicator cell line). |
| Reconstitution Instructions | Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not to be used in humans |
Details
HGH is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. HGH can promote bone and cartilage growth as well as increase protein synthesis through liver somatomedin and tissue polypeptide growth factor, correct the post-traumatic state of negative nitrogen and hypoproteinemia induced by severe infection and cirrhosis; stimulate immunoglobulin synthesis, stimulate the proliferation of lymphoid tissue, macrophages and lymphocyte, and accelerate wound healing; promote myocardial protein synthesis, increase myocardial contractility and reduce myocardial oxygen consumption; regulating fat metabolism, reducing serum cholesterol, low - density lipoprotein level.
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Vera Chesnokova, Excess growth hormone suppresses DNA damage repair in epithelial cells. JCI Insight, Feb 2019; 30728323.
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