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Human CellExp™ Her2 / ErbB2, Mouse Recombinant

Involved in the signal transduction pathways leading to cell growth and differentiation.
Catalog #: P1345
SKU-Size Size Price Qty
P1345-10 10 μg
$95.00
P1345-50 50 μg
$345.00
More Sizes Get Quote

Product Details

Alternate Name erbB-2, MNL 19, CD340, Neu, c-ErbB-2, NEU, NGL, TKR1
Gene Symbol ERBB2
Gene ID 13866
Accession # Q80Y89
Source HEK 293 cells
Appearance Lyophilized
Physical Form Description Lyophilized
Molecular Weight ~93 kDa (C terminal 6×His tag)
Purity by SDS-PAGE >95%
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile PBS (pH 7.4). Do not vortex.
Amino Acid Sequence Thr 23 - Thr 653
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Mouse Her2/ErbB2 includes the extracellular domain from the full length protein. Her2 is a tyrosine kinase that is widely expressed in epithelial cells and the synaptic sites of muscle fibers. It forms heterodimer with EGFR (ErbB1), ERBB3 and ERBB4 to form high affinity signaling complexes. Her2 has been found to be over-expressed in a large number of breast carcinomas. Approximately 30% of breast cancers have amplifications of the HER2 gene or overexpression of its protein product. Her2 also plays roles in development, communication at the neuromuscular junction and regulation of cell growth and differentiation.


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