Product Details
| Alternate Name | erbB-2, MNL 19, CD340, Neu, c-ErbB-2, NEU, NGL, TKR1 |
|---|---|
| Gene Symbol | ERBB2 |
| Gene ID | 2064 |
| Accession # | P04626 |
| Source | HEK 293 cells |
| Appearance | Lyophilized |
| Physical Form Description | Lyophilized from 0.22 μm filtered solution in PBS pH 7.4. Generally 5-8% Mannitol or Trehalose is added as a protectant before lyophilization. |
| Molecular Weight | 70.6 kDa |
| Purity by | > 95% |
| Biological Activity | Immobilized Human Her2 (ED) at 0.05 μg/ml (100 μl/well) can bind trastuzumab (Herceptin) with a linear range of 0.05-3 ng/ml. |
| Reconstitution Instructions | Reconstitute in sterile deionized water to a concentration up to 0.2 mg/ml. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | Lyophilized protein can be stored at 4°C. Once reconstituted store at -80°C in small aliquots. |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2, HER-2 /neu, NEU, NGL, TKR1 and c-erb B2, and is a protein involved in higher aggressiveness of breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30% of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation.
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