Product Details
| Alternate Name | ERBB2, CD340, HER-2/neu, HER2, MLN19, NEU, NGL, TKR1 |
|---|---|
| Gene Symbol | ErbB2 |
| Gene ID | 102146608 |
| Accession # | XP_005584091.2 |
| Source | HEK293 cells |
| Appearance | Lyophilized |
| Physical Form Description | Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Generally Trehalose is added as a protectant before lyophilization. |
| Molecular Weight | 71.2 kDa |
| Purity by SDS-PAGE | ≥95% |
| Endotoxin Level | <1 EU/μg by LAL method |
| Biological Activity | Immobilized Trastuzumab at 2 μg/mL (100 μL/well) can bind Cynomolgus Her2 with a linear range of 2-6 ng/mL |
| Reconstitution Instructions | Reconstitute in sterile deionized water to a concentration of 50 μg/ml. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not to be used in humans |
Details
Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2, HER-2 /neu, NEU, NGL, TKR1 and c-erb B2, and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30% of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation.
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