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Human CellExp™ HDAC8, Human Recombinant, Active

Critical regulator of transcription, cell cycle progression, and developmental events
Catalog #: P1266

In stock


Product Details

Cat # +Size P1266-50
Size 50 μg
Alternate Name HDACL1, HD8, Histone Deacetylase 8, CDA07
Gene Symbol HDAC8
Gene ID 55869
Accession # Q9BY41
Source HEK293 cells
Appearance Liquid
Physical Form Description In 30 mM HEPES, 140 mM NaCl, 10 mM KCl, 3% glycerol, 0.25 mM TCEP, pH 7.5
Molecular Weight 41 kDa
Purity by SDS-PAGE ≥95%
Handling Thaw on ice, and aliquot into smaller working quantities to avoid multiple freeze/thaw cycles.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans


Human Histone Deacetylase 8 (HDAC8) is a member of the class I Histone Deacetylases. HDACs are important enzymes for the transcriptional regulation of gene expression in eukaryotic cells. HDACs catalyze the removal of acetyl groups from lysines near the N-termini of histones. Human HDACs have been implicated in a variety of human diseases such as cardiomyopathy, osteodystrophy, neurodegenerative disorders, aging and cancer. Expression of HDAC8 is restricted to cells showing smooth muscle differentiation in normal human tissue and is a novel marker of smooth muscle differentiation. Like other class I and II HDAC members, the activity of HDAC8 is sensitive to HDAC inhibitor Trichostatin A (TSA).

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