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Human CellExp™ HDAC6, Human Recombinant, Active

Regulates the acetylation status of non-histone substrates
Catalog #: P1265

In stock

$365.00

Product Details

Cat # +Size P1265-50
Size 50 μg
Alternate Name KIAA0901, JM21, HD6
Gene Symbol HDAC6
Gene ID 10013
Accession # Q9UBN7
Source HEK293 cells
Appearance Liquid
Physical Form Description In 30 mM HEPES, 140 mM NaCl, 10 mM KCl, 3% glycerol, 0.25 mM TCEP, pH 7.4
Molecular Weight 131 kDa
Purity by SDS-PAGE ≥90%
Handling Thaw on ice, and aliquot into smaller working quantities to avoid multiple freeze/thaw cycles.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

HDAC6 is a Class II HDAC. It is unique among human HDACs in having two full deacetylase domains. As a tubulin deacetylase, HDAC6 may act to promote autophagic clearing of Huntington aggregates and retard HIV1 infection. It can shuttle between the nucleus and cytoplasm, suggesting potential extra nuclear functions by regulating the acetylation status of non-histone substrates. By modifying chromatin structure and other non-histone proteins, HDACs play important roles in controlling complex biological events, including cell development, differentiation, programmed cell death, angiogenesis, and inflammation. Considering these major roles, it is conceivable that dysregulation of HDACs and subsequent imbalance of acetylation and deacetylation may be involved in the pathogenesis of various diseases, including cancer and inflammatory diseases.


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