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Human CellExp™ HDAC5, Catalytic Domain, Human Recombinant, Active

Key epigenetic regulator
Catalog #: P1268

In stock

$365.00

Product Details

Cat # +Size P1268-50
Size 50 μg
Alternate Name HDAC5, HD5, Histone Deacetylase 5, Antigen NY-CO-9, KIAA0600
Gene Symbol HDAC5
Gene ID 10014
Accession # Q9UQL6
Source HEK293 cells
Appearance Liquid
Physical Form Description In 30 mM HEPES, 140 mM NaCl, 10 mM KCl, 3% glycerol, 0.25 mM TCEP, pH 7.6
Molecular Weight 45 kDa
Purity by SDS-PAGE ≥95%
Handling Thaw on ice, and aliquot into smaller working quantities to avoid multiple freeze/thaw cycles.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not For Use in Humans.

Details

Human HDAC5 is composed of 1122 amino acid residues. The deacetylase domain of HDAC5 is located at the C-terminal half of the molecule. The N-terminal non-deacetylase domain does not show any significant homology with any published sequence. Both domains are required for HDAC5- mediated repression of gene transcription. HDAC5 interacts with a growing number of transcriptional factors including MEF2A as well as other HDAC proteins. The interacting complexes bind to specific regions of chromatin and regulate gene transcription in these regions.


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