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Human CellExp™ HDAC11, Human Recombinant, Active

A member of the Class IV HDAC subfamily
Catalog #: P1267

In stock


Product Details

Cat # +Size P1267-50
Size 50 μg
Alternate Name HDAC11, HD11, Histone Deacetylase 11
Gene Symbol HDAC11
Gene ID 79885
Accession # Q96DB2
Source HEK293 cells
Appearance Liquid
Physical Form Description In 30 mM HEPES, 140 mM NaCl, 10 mM KCl, 3% glycerol, 0.25 mM TCEP, pH 7.6
Molecular Weight 84 kDa
Purity by SDS-PAGE ≥80%
Handling Thaw on ice, and aliquot into smaller working quantities to avoid multiple freeze/thaw cycles.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans


HDAC11 is a 39kDa protein and belongs to the Histone Deacetylase Class IV subfamily. The enzyme is primarily localized in the nucleus and shows high expression in specific tissues like brain, heart, skeletal muscle and kidney. It is the newest member of the HDAC family and hence very little is known about its functional role. Initial studies identified HDAC11 as a negative regulator of IL-10 production in APC cells. A recent study shows that HDAC11 is the most efficient fatty acid deacetylase of the HDAC family with catalytic efficiencies towards dodecanoylated and myristoylated substrates exceeding 70,000 M-1 s -1. Increasing body of evidence indicate a possible involvement of HDAC11 in diverse pathophysiological processes including immunomodulation, cancer pathogenesis, cellular differentiation etc

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