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Human CellExp™ HAVCR1 / KIM1 / TIM1, human recombinant

May be involved in the moderation of asthma and allergic diseases
Catalog #: 7494
SKU-Size Size Price Qty
7494-10 10 μg
$180.00
7494-50 50 μg
$615.00
More Sizes Get Quote

Product Details

Alternate Name HAVCR1, HAVCR, HAVCR-1, KIM-1, KIM1, TIM, TIM-1, TIM1, TIMD-1, TIMD1, Hepatitis A virus cellular receptor 1
Gene Symbol HAVCR1
Gene ID 26762
Accession # Q96D42
Source HEK293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
Molecular Weight This protein contains a poly histidine tag at C-terminus and has a calculated MW of 31.3 kDa after removal of signal peptide. In DTT-reduced SDS-PAGE, rhHAVCR1 protein migrates as 80-100 kDa poly peptide due to high glycosylation.
Purity by SDS-PAGE ≥90%
Endotoxin Level <1 EU/μg by LAL method
Biological Activity Measured by its ability to inhibit anti-CD3 induced proliferation of stimulated human T cells. Human T lymphocytes cultured for 72 hours with PHA were incubated for an additional 3 days in 96 well plates coated with 500 ng/ml anti-CD3 and rhTIM1. The ED50
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Hepatitis A virus cellular receptor 1 also known as HAVCR1, HAVCR, KIM1, TIM, TIM1, TIMD1, is widely expressed with highest levels in kidney and testis. The protein encoded by HAVCR1 gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. Three transcript variants encoding the same protein have been found for this gene. HAVCR1 may play a role in T-helper cell development, the regulation of asthma and allergic diseases and in kidney injury and repair. In case of human hepatitis A virus (HHAV) infection, functions as a cell-surface receptor for the virus.


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