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Product Details
| Cat # +Size | 7233-10 |
|---|---|
| Size | 10 μg |
| Alternate Name | GZMB, CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT, Fragmentin-2, Granzyme B, Granzyme-2, GRB |
| Gene Symbol | GZMB |
| Gene ID | 3002 |
| Accession # | P10144 |
| Source | HEK 293 cells |
| Appearance | Lyophilized powder |
| Physical Form Description | Lyophilized from 0.22 μm filtered solution in PBS. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization. |
| Molecular Weight | ~27 kDa |
| Purity by SDS-PAGE | ≥95% |
| Biological Activity | Assay was performed using BioVision’s Granzyme B Activity Fluorometric Assay Kit (Catalog #: K168). The activity of Granzyme B was determined using 100 µM substrate Ac-IETD-AFC in a buffer containing 50 mM HEPES pH 7.5, 10 mM CaCl2 at 37°C with an activit |
| Reconstitution Instructions | Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4. Do not vortex. Store the solution in aliquots at -20°C for long-term storage. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not to be used in humans |
Details
Granzyme B (GZMB) is a serine protease stored in granules of activated cytotoxic T cells and NK cells. Upon target cell contact, granzyme B is directionally exocytosed and assisted by perforin, enters the target cell. With its unique substrate specificity (granzyme B cleaves after Asp), granzyme B processes and activates various pro-caspases thereby inducing apoptosis in the target cell. Elevated abundance of Granzyme B is also implicated in autoimmune diseases, skin disorders and type 1 diabetes.
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Laura C. Burzynski
, The Coagulation and Immune Systems Are Directly Linked through the Activation of Interleukin-1α by Thrombin
. Immunity
, Apr 2019; 30926232.
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