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Human CellExp™ Granzyme B, human recombinant

Involved in target cell lysis in cell-mediated immune responses
Catalog #: 7233
$385.00

Product Details

Cat # +Size 7233-10
Size 10 μg
Alternate Name GZMB, CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT, Fragmentin-2, Granzyme B, Granzyme-2, GRB
Gene Symbol GZMB
Gene ID 3002
Accession # P10144 
Source HEK 293 cells
Appearance Lyophilized powder
Physical Form Description Lyophilized from 0.22 μm filtered solution in PBS. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
Molecular Weight ~27 kDa
Purity by SDS-PAGE ≥95%
Biological Activity The activity of Granzyme B was determined using 100 µM substrate Ac-IETD-AFC in a buffer containing 50 mM HEPES pH 7.5, 10 mM CaCl2 at 37°C.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4. Do not vortex. Store the solution in aliquots at -20°C for long-term storage.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Granzyme B (GZMB) is a serine protease stored in granules of activated cytotoxic T cells and NK cells. Upon target cell contact, granzyme B is directionally exocytosed and assisted by perforin, enters the target cell. With its unique substrate specificity (granzyme B cleaves after Asp), granzyme B processes and activates various pro-caspases thereby inducing apoptosis in the target cell. Elevated abundance of Granzyme B is also implicated in autoimmune diseases, skin disorders and type 1 diabetes.


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