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Human CellExp™ GM-CSF R alpha, Human Recombinant

Transduces signal for proliferation, differentiation, and functional activation of hematopoietic cells.
Catalog #: P1380

In stock

SKU-Size Size Price Qty
P1380-10 10 µg
$95.00
P1380-50 50 µg
$395.00
More Sizes Get Quote

Product Details

Alternate Name GM-CSF R alpha, GM-CSF-R-alpha, GMCSFR-alpha, GMR-alpha, CSF2RA, CSF2R, CSF2RY, CDw116, CD116
Gene Symbol CSF2RA
Gene ID 1438
Accession # P15509
Source HEK 293 cells
Appearance Lyophilized powder
Physical Form Description Lyophilized
Molecular Weight This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 36.4 kDa. The protein migrates as 60-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation
Purity by SDS-PAGE >95% as determined by SDS-PAGE
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile deionized water to a concentration of 100 µg/ml. Do not vortex. It is recommended to store at -20°C.C.
Amino Acid Sequence AA Glu 23 - Gly 320
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

GM-CSF R alpha(Granulocyte-macrophage colony-stimulating factor receptor subunit alpha) is also known as CSF2RA, CD116, GMR-alpha. Low affinity receptor for granulocyte-macrophage colony-stimulating factor. Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells. Hereditary pulmonary alveolar proteinosis (hPAP) is a rare disorder of pulmonary surfactant accumulation and hypoxemic respiratory failure caused by mutations in CSF2RA (encoding the granulocyte/macrophage colony-stimulating factor [GM-CSF] receptor α-chain [CD116]), which results in reduced GM-CSF-dependent pulmonary surfactant clearance by alveolar macrophages.


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