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Human CellExp™ Glypican 2 / GPC2, Mouse Recombinant

Cell surface proteoglycan that bears heparan sulfate.
Catalog #: P1488
SKU-Size Size Price Qty
P1488-10 10 μg
$110.00
P1488-50 50 μg
$395.00
More Sizes Get Quote

Product Details

Alternate Name Glypican 2, GPC2
Gene Symbol Gpc2
Gene ID 71951
Accession # Q8BKV1
Source HEK 293 cells
Appearance Lyophilized powder
Physical Form Description Lyophilized
Molecular Weight This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 60.6 kDa. The protein migrates as 35-40 kDa under reducing (R) condition (SDS-PAGE).
Purity by >95%
Endotoxin Level Less than 1.0 EU per μg by the LAL method.
Reconstitution Instructions Reconstitute in sterile deionized water to the desired protein concentration.
Amino Acid Sequence AA His 22 - Ser 556
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Glypican 2 (GPC2), also known cerebroglycan, is a glycophosphatidylinositol-linked integral membrane heparan sulfate proteoglycan found in the developing nervous system. Cerebroglycan participates in cell adhesion and is thought to regulate the growth and guidance of axons. Cerebroglycan has especially high affinity for laminin-1. GPC2 silencing inactivates Wnt/β-catenin signaling and reduces the expression of N-Myc, an oncogenic driver of neuroblastoma tumorigenesis. Immunotoxins and chimeric antigen receptor (CAR) T cells targeting GPC2 inhibit neuroblastoma growth in mouse models. A GPC3 specific antibody drug conjugate (ADC) can also inhibit neuroblastoma cell proliferation.


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