Human CellExp™ GITR / TNFRSF18, Human recombinant

Tumor necrosis factor receptor superfamily member 18
Catalog #: 9231 | abID:

Product Details

Alternate Name AITR, GITR, TNFRSF18, CD357
Gene Symbol TNFRSF18
Gene ID 8784
Accession # Q9Y5U5-1
Source HEK 293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
Molecular Weight This protein is fused with a 6× His tag at C-terminus and has a calculated MW of 15.4 kDa. The protein migrates as 22-25 kDa in SDS-PAGE due to glycosylation.
Purity by SDS-PAGE ≥92%
Purity by ≥92%
Endotoxin Level < 1 EU/μg
Biological Activity Immobilized Human GITR/TNFRSF18, His Tag at 2 µg/mL (100 µL/well) can bind r-Human GITR Ligand /TNFSF18 with a linear range of 0.8-25 ng/mL.
Reconstitution Instructions Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/ml
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Glucocorticoid-induced TNFR-related protein (GITR) is also known as Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), activation-inducible TNFR family receptor (AITR), CD antigen CD357, which is a member of the tumor necrosis factor receptor (TNF-R) superfamily. GITR is receptor for TNFSF18, which seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR also mediated NF-kappa-B activation via the TRAF2/NIK pathway.


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