Human CellExp™ GITR Ligand / TNFSF18 Fc Tag, Mouse recombinant

Tumor necrosis factor receptor superfamily member 18
Catalog #: P1126 | abID: ab219721

Product Details

abID ab219721
Alternate Name TNFSF18, AITRL, TL6, hGITRL, GITR Ligand
Gene Symbol Tnfsf18
Gene ID 240873
Accession # Q7TS55
Source HEK 293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Trehalose is added as protectant before lyophilization.
Molecular Weight 41.4 kDa
Purity by SDS-PAGE > 95%
Endotoxin Level < 1.0 EU per/μg
Biological Activity Immobilized Mouse GITR, His Tag at 10μg/mL (100 μL/well) can bind Mouse GITR Ligand, Fc Tag with a linear range of 0.007-0.256 μg/mL.
Reconstitution Instructions Reconstitute in sterile deionized water to the desired protein concentration.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Tumor necrosis factor ligand superfamily member 18 (TNFSF18) is also known as Glucocorticoid - induced TNF-related ligand (GITRL or GITR Ligand), Activation - inducible TNF - related ligand (AITRL), which belongs to the tumor necrosis factor family. TNFSF18 is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 / GITRL is up-regulated after stimulation by bacterial lipopolysaccharides (LPS). TNFSF18 Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. TNFSF18 / GITR Ligand is important for interactions between activated T-lymphocytes and endothelial cells. TNFSF18 also mediates activation of NF-kappa-B.


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