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Human CellExp™ GFRA2 / GDNFRB, Human Recombinant

Mediates activation of RET signaling
Catalog #: P1736
SKU-Size Size Price Qty
P1736-10 10 µg
$195.00
P1736-50 50 µg
$325.00
More Sizes Get Quote

Product Details

Alternate Name GDNF Family Receptor Alpha-2; GDNF Receptor Beta; Neurturin Receptor Alpha; RET Ligand 2
Gene ID 2675
Accession # O00451
Source HEK293 cells
Appearance Lyophilized protein
Physical Form Description Lyophilized powder
Molecular Weight ~60 to 85 kDa due to glycosylation
Purity by SDS-PAGE > 95%
Formulation Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2
Endotoxin Level < 1.0 EU per µg as determined by the LAL method
Reconstitution Instructions Reconstitute using sterile deionized water. Do not vortex.
Amino Acid Sequence Ser 22 to Ser 441 with C-terminal 6xHis Tag
Handling Centrifuge the vial prior to opening.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

The GFRA2 receptor is a surface receptor attached to the cell membrane by a glycosylphosphatidylinositol linkage. GFRA2 is a receptor for glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) and mediates activation of the RET receptor tyrosine kinase. GFRA2 is a candidate target for the study of RET-associated diseases.


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