Human CellExp™ Frizzled-5 / FZD5 Protein, Human recombinant

Catalog #: P1028 | abID:

Product Details

Gene Symbol FZD5
Gene ID 7855
Accession # Q13467
Source HEK 293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered solution in PBS, pH 7.5. Generally Mannitol or Trehalose is added as a protectant before lyophilization.
Molecular Weight 42.6 kDa
Purity by SDS-PAGE > 95%
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Frizzled‐5 (FZD5) is also known as FzE5, which belongs to the G‐protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta‐catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK‐3 kinase, nuclear accumulation of beta‐catenin and activation of Wnt target genes. FZD5 contains one FZ (frizzled) domain. FZD5 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. FZD5 interacts specifically with Wnt5A to induce the beta‐catenin pathway. FZD5 interacts with GOPC.


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