Human CellExp™ Frizzled-4 / FZD4 Protein, Human recombinant

Catalog #: P1027 | abID:

Product Details

Alternate Name FZD4, Frizzled-4, CD344, Fz-4, hFz4, FzE4
Gene Symbol FZD4
Gene ID 8322
Accession # Q9ULV1
Source HEK 293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered solution in PBS pH 7.5. Generally Mannitol or Trehalose is added as a protectant before lyophilization.
Molecular Weight 42.9 kDa
Purity by SDS-PAGE > 95%
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Frizzled-4 (FZD4) is also known as FzE4, CD344, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD4 contains one FZ (frizzled) domain. FZD4 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. FZD4 interacts with MAGI3 and norrin (NDP).


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