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Human CellExp™ Frizzled-2 / FZD2 Protein, Human recombinant

Catalog #: P1026
SKU-Size Size Price Qty
P1026-10 10 μg
$100.00
P1026-50 50 µg
$365.00
More Sizes Get Quote

Product Details

Alternate Name FZD2, Frizzled-2, Fz-2, hFz2, FzE2
Gene Symbol FZD2
Gene ID 2535
Accession # Q14332
Source HEK 293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered solution in 50 mM tris, 100 mM glycine, pH 7.5.
Molecular Weight 41.7 kDa
Purity by SDS-PAGE > 95%
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 µg/ml. Do not vortex.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Frizzled-2 (FZD2) is also known as FzE2, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD2 contains one FZ (frizzled) domain. FZD2 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. The Lys-Thr-X-X-X-Trp motif of FZD2 interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.


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