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Human CellExp™ FOLR1, Fc Tag, Human Recombinant

Mediates delivery of 5-methyltetrahydrofolate to the interior of cells
Catalog #: P1339
SKU-Size Size Price Qty
P1339-10 10 μg
$85.00
P1339-50 50 μg
$345.00
More Sizes Get Quote

Product Details

Alternate Name FOLR1, FBP, FOLR, FOLR-1, Folate-receptor-alpha
Gene Symbol FOLR1
Gene ID 2348
Accession # P15328
Source HEK293 cells
Appearance Lyophilized
Physical Form Description Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.
Molecular Weight 51.3 kDa
Purity by SDS-PAGE ≥95%
Endotoxin Level < 1.0 EU per/μg
Biological Activity Immobilized Folic acid-BSA conjugate at 5 μg/mL (100 μL/well) can bind Human FOLR1, Fc Tag with a linear range of 10-78 ng/mL
Reconstitution Instructions Reconstitute in sterile deionized water to a concentration of 50 μg/ml.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans

Details

Folate Receptor 1 (FOLR1) also known as Folate receptor alpha, Folate Binding Protein (FBP), FOLR, and is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Mature FOLR1 is an N-glycosylated protein that is anchored to the cell surface by a GPI linkage. FOLR1 is predominantly expressed on epithelial cells and is dramatically upregulated on many carcinomas. FOLR1 is internalized to the endosomal system where it dissociates from its ligand before recycling to the cell surface. A soluble form of FOLR1 can be proteolytically shed from the cell surface into the serum and breast milk. Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD). NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life.


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